Noninvasive modulation of subcallosal cingulate and depression with focused ultrasonic waves
Biological Psychiatry
2024
Thomas S. Riis, Daniel A. Feldman, Sarah S. Kwon, Lily C. Vonesh, Vincent Koppelmans, Jefferson R. Brown, Daniela Solzbacher, Jan Kubanek, Brian J. Mickey
This article shows that Diadem applied to the subcallosal cingulate cortex provides a rapid and sustained improvement in depresssive symptoms.
Noninvasive targeted modulation of pain circuits with focused ultrasonic waves
PAIN
2024
Riis T, Feldman D, Losser A, Okifuji A, Kubanek J
This article shows that Diadem applied to the cingulate cortex provides a rapid and sustained improvement in pain intensity.
Controlled ultrasonic interventions through the human skull
Frontiers in Human Neuroscience
2024
Wilson M, Riis T, Kubanek J
This article shows that Diadem’s correction for the head is critical for effective neuromodulation.
Controlled noninvasive modulation of deep brain regions in humans
Nature Communications Engineering
2024
Riis T, Feldman D, Mickey B, Kubanek J
This article highlights the unique feature of the device: Its ability to measure and compensate for the severe and unpredictable distortion of ultrasound by the head and hair.
Device for multifocal delivery of ultrasound into deep brain regions in humans
IEEE Transactions on Biomedical Engineering
2024
Riis T, Feldman D, Losser A, Mickey B, Kubanek J
This publication describes Diadem and its function in detail.
Noninvasive modulation of essential tremor with focused ultrasonic waves
Journal of Neural Engineering
2024
Riis T, Moretti P, Losser A, Kassavetis P, Kubanek J.
This article shows that Diadem modulation of a deep brain thalamic region can supress the magnitude of essential tremor.
Durable effects of deep brain ultrasonic neuromodulation on major depression: a case report
Journal of Medical Case Reports
2023
Riis T, Feldman D, Vonesh L, Brown J, Solzbacher D, Kubanek J, Mickey B
This article shows that Diadem applied to the subgenual cingulate cortex provides a rapid and sustained improvement in depressive symptoms.